Abstract: In order to study the freeze-thaw response law of the slope supporting structure in seasonal frozen soil area when seasonal temperature changes periodically, the freeze-thaw model simulation system of slope supporting structure in seasonal frozen soil area was developed, and the experimental study of frame anchoring slope supporting structure in seasonal frozen soil area was carried out.The simulation system is mainly composed of four parts: a movable open-body automatic temperature control frozen soil laboratory, a model box, a slope support structure model, and a temperature-moisture-stress multi-physical field test system, which realizes the proportion compatibility between the structure and the soil in the model test and the micro-environment simulation in which the temperature automatically fluctuates in the form of a sinusoidal function when the seasonal changes in the seasonal frozen soil area alternates.At the same time, it has the functions of visual observation of experimental phenomena and automatic collection of multi-physics experimental data.The simulation system is applied to the freeze-thaw model test of frame anchoring slope supporting structure.By analyzing the temperature, moisture and frost heaving force of supporting structure at different positions of slope, the freeze-thaw response law of slope supporting structure under alternating cold and warm environment is revealed.The reliability and accuracy of the simulation system are preliminarily verified by comparing the test results with the measured data in the literature.The methods and results of the freeze-thaw model simulation system in this paper can provide important reference value for the engineering design of cold region slope.