Abstract: Trend analysis was used to explore the spatial and temporal patterns of vegetation normalized difference vegetation index(NDVI) in the Three Gorges Reservoir Area(TGRA) and its relationship with elevation.Through Mann-Kendall test, the mutation points of NDVI change was identified.The correlation and its driving partition of regional NDVI and climate, human factors were clarified.The results show that:(1) From 2000 to 2019,the average NDVI in the TGRA showed a rising trend of fluctuation, and its spatial distribution heterogeneity was obvious, which shows a increase first and then decrease slightly with regional elevation rising;(2) The increasing trend of NDVI was obvious from 2000 to 2008,and its growth rate slowed down after 2009;(3) Areas where climate was the main factor affecting NDVI accounted for 8.9% of the total research area, whereas human activities were the primary factor influencing NDVI changes.Among them, ecological projects such as returning farmland to forests have a positive effect, while urbanization and economic development have a negative effect.It is urgent to take corresponding measures to realize the benign interaction between the regional economy and the ecosystem.