Abstract: The complex pore-fracture structures of blasting simulated sandstone-type uranium deposits and the multiple factors affecting the leaching solution migration of make it difficult to accurately predict the permeability during the in-situ leaching.Therefore,in this paper,the key factors controlling the permeability of blasting simulated sandstone-type uranium deposits is first clarifies;secondly,a stress-time-chemical multi-field coupling model for permeability in in-situ leaching of blasting simulated sandstone-type uranium deposits is established;finally,the permeability evolution law of Shihongtan uranium deposit in Xinjiang after blasting is analyzed,and the permeability evolution mechanism throughout the entire process of blasting stimulation and in-situ leaching is elucidated.Results show that the established permeability model has a maximum error of less than 4.36% compared to existing research results,demonstrating good reliability and accuracy,and can be used to predict the permeability of blasting stimulated sandstone-type uranium deposits during in-situ leaching.The permeability of the Shihongtan uranium deposit in Xinjiang exhibits a phased variation pattern of “rapid decrease-slow decrease-stabilization” over time during in-situ leaching,and shows a linear decreasing trend with increasing effective stress.Chemical reactions have a significant impact on permeability in the early stage of in-situ leaching,while creep effects dominate the permeability changes in the later stage.By adjusting the injection pressure of leaching solution,the permeability of uranium deposits can be improved to some extent.To maintain high permeability continuously,it is recommended to adopt measures such secondary reservoir stimulation.The research findings provide a theoretical basis for predicting and evaluating the permeability of blasting stimulated sandstone-type uranium deposits during in-situ leaching.